Cancer and neurodegeneration meet
نویسنده
چکیده
What is molecular medicine? My view is that it is the scientific discipline that applies the tool-box of molecular biology to understand the pathogenesis of disease. Ideally such work translates into novel diagnostics and novel drug targets and treatments. It is clear that molecular medicine is not only borrowing knowledge and tools from other life sciences, but the field is itself also driving the development of novel technologies and the creation of new insights in biology. In fact, the nature of molecular medicine research, oriented towards pathophysiological processes, systems and models makes this field one of the spearheads of the rapid evolution in life sciences. Molecular genetics is exemplary in that regard; the massive investments made to sequence and annotate the human genome and to refine the analysis of genetic information were only possible because of the idea that medical benefits will emerge down the line. Obviously all life sciences profit from this boost.
منابع مشابه
P142: Inflammation or Neurodegeneration: Which one has Remarkable Role in Multiple Sclerosis?
Multiple Sclerosis (MS) is a complex disease resulting from the occurrence of intermingled episodes of neuroinflammation and degeneration. However, this concept has recently challenged by several observations suggesting that in this disease neurodegeneration might occur independently of inflammation. The evidence that active neurodegeneration in MS is invariably associated with inflammation is p...
متن کاملAttenuation Effect of Cannabinoid Type 1 Receptor Activation on Methamphetamine-Induced Neurodegeneration and Locomotion Impairments among Male Rats
Background: A number of neuroimaging studies on human addicts have revealed that abuse of Methamphetamine (METH) can induce neurodegenerative changes in various brain regions like the cerebral cortex and cerebellum. Although the underlying mechanisms of METH-induced neurotoxicity have been studied, the cellular and molecular mechanisms of METH-induced neurotoxicity remain to be clarified. Previ...
متن کاملLornoxicam Alone and with Selegiline Improves the Neuroprotective Effect and Cognition in Scopolamine Induced Neurodegeneration and Cognitive Impairment in Rats
Alzheimer is a progressive neurodegenerative disorder in which Oxidative stress plays a major role. The present study was designed to investigate Neuroprotective effect of Lornoxicam, Selegiline and co-administration of both drugs in Scopolamine induced cognitive impairment and neurodegeneration. Scopolamine (1.4mg/kg) was administered intraperitoniallyin male Wistar rats. Rectangular maze perf...
متن کاملP 97: Neurodegeneration Induced by Tau protein
Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...
متن کاملPharmacological evidence for lithium-induced neuroprotection against methamphetamine-induced neurodegeneration via Akt-1/GSK3 and CREB-BDNF signaling pathways
Objective(s): Neurodegeneration is an outcome of Methamphetamine (METH) abuse. Studies have emphasized on the neuroprotective properties of lithium. The current study is designed towards evaluating the role of Akt-1/GSK3 and CREB-BDNF signaling pathways in mediating lithium neuroprotection against METH-induced neurodegeneration in rats. Materials and ...
متن کاملCrocin Acting as a Neuroprotective Agent against Methamphetamine-induced Neurodegeneration via CREB-BDNF Signaling Pathway
Methamphetamine (METH) abuse causes neurodegeneration. Medicinal herb such as crocin has neuroprotective properties. The current study evaluates the role of CREB-BDNF signaling pathway in mediating the neuroprotective effects of crocin against METH-induced neurodegeneration in rats. Sixty adult male rats were divided randomly into group 1 and group 2 which received 0.7 mL/rat ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2010